--- topic: "Alkaline Water" title: "Does Alkaline Water Do Anything?" order: 1 description: "Blood pH is tightly regulated, and the few small trials of alkaline water are short and inconsistent. What the research actually shows, and what it does not." question: "Is alkaline water healthier than plain water?" answer: "Alkaline water may not be healthier than plain water: your body keeps blood pH steady regardless, and the few small trials are short and inconsistent." actions: - "Drink plain tap or filtered water; if you like how alkaline water tastes, treat it as a preference, not a treatment [1][5]." - "For reflux, start with the lifestyle steps and options in [acid reflux](/acid-reflux/natural-management); alkaline water has only been tested against the stomach enzyme pepsin in a lab dish [8]." - "If you compare products, look at the bicarbonate and mineral content on the label rather than the pH number, since a high pH by itself adds almost no alkali [1][9]." cautions: - "With kidney disease or potassium-affecting drugs such as diuretics, ask a clinician before drinking much alkaline water; one case report described severe alkalosis after about 5 liters a day [11]." - "Do not use alkaline water or an alkaline diet to treat cancer or any serious disease: a systematic review found no studies showing benefit [5]." - "Stone formers prescribed urine alkalinization should follow their clinician's plan; commercial alkaline water has negligible alkali compared with prescribed treatments [1]." confidence: 2 confidenceNote: "A handful of small, short trials measured indirect markers (viscosity, bone turnover, uric acid), reviews found no support for bone or cancer claims, and no trial tested disease outcomes." evidenceSummary: rctCount: 3 observationalCount: 1 metaAnalysisCount: 2 totalParticipants: "500+" replicated: false newestStudyYear: 2025 references: - id: "1" pmid: "38193415" title: "Alkaline Water: Help or Hype for Uric Acid and Cystine Urolithiasis?" authors: "Piedras P, Cumpanas AD, McCormac A, et al." year: 2024 journal: "J Urol" - id: "2" pmid: "29939584" title: "Physiology, Acid Base Balance" authors: "Hopkins E, Sanvictores T, Sharma S" year: 2022 journal: "StatPearls" - id: "3" pmid: "26597304" title: "Acid-Base Homeostasis" authors: "Hamm LL, Nakhoul N, Hering-Smith KS" year: 2015 journal: "Clin J Am Soc Nephrol" - id: "4" pmid: "21529374" title: "Causal assessment of dietary acid load and bone disease: a systematic review & meta-analysis applying Hill's epidemiologic criteria for causality" authors: "Fenton TR, Tough SC, Lyon AW, et al." year: 2011 journal: "Nutr J" - id: "5" pmid: "27297008" title: "Systematic review of the association between dietary acid load, alkaline water and cancer" authors: "Fenton TR, Huang T" year: 2016 journal: "BMJ Open" - id: "6" pmid: "27932937" title: "Effect of electrolyzed high-pH alkaline water on blood viscosity in healthy adults" authors: "Weidman J, Holsworth RE Jr, Brossman B, et al." year: 2016 journal: "J Int Soc Sports Nutr" - id: "7" pmid: "20836884" title: "Acid-base balance and hydration status following consumption of mineral-based alkaline bottled water" authors: "Heil DP" year: 2010 journal: "J Int Soc Sports Nutr" - id: "8" pmid: "22844861" title: "Potential benefits of pH 8.8 alkaline drinking water as an adjunct in the treatment of reflux disease" authors: "Koufman JA, Johnston N" year: 2012 journal: "Ann Otol Rhinol Laryngol" - id: "9" pmid: "18926940" title: "Alkaline mineral water lowers bone resorption even in calcium sufficiency: alkaline mineral water and bone metabolism" authors: "Wynn E, Krieg MA, Aeschlimann JM, et al." year: 2009 journal: "Bone" - id: "10" pmid: "41515223" title: "A Pilot Randomized Controlled Trial and Multi-Omics Analysis of Electrolysed Alkaline Water: Impacts on Gut Microbiota and Metabolic Signatures in Hyperuricemia" authors: "Liu Q, Gu W, Ma J, et al." year: 2025 journal: "Nutrients" - id: "11" pmid: "38097490" title: "Severe Alkalemia and hypokalemia after chronic exposure to alkaline water" authors: "Rizvi K, Abraham S, Gong J, et al." year: 2024 journal: "Am J Emerg Med" - id: "12" pmid: "36315555" title: "Associations of alkaline water with metabolic risks, sleep quality, muscle strength: A cross-sectional study among postmenopausal women" authors: "Chan YM, Shariff ZM, Chin YS, et al." year: 2022 journal: "PLoS One" --- Alkaline water is plain or mineral water with a pH above 7 (7 is neutral); commercial bottles measured about 9.7 to 10.2 [1]. Your blood stays near pH 7.4 whatever you normally drink, because your kidneys and lungs regulate it tightly [2][3]. A few small, short trials found changes in indirect markers, none tested disease outcomes, and reviews found no support for the bone and cancer claims [4][5]. It is probably harmless, and probably unnecessary. ## How it works **What “alkaline” means.** pH measures acidity on a scale where 7 is neutral. Alkaline waters are made by electrolysis, by adding mineral concentrates, or come from springs rich in bicarbonate [6][7][8]. The pH number says little about what the water can do in the body. In five commercial brands, pH ran 9.69–10.15, yet the physiologic alkali content was under 1 mEq/L, far below potassium citrate or even some ordinary drinks used to alkalinize urine [1]. **Your body sets blood pH.** Blood pH is held between 7.35 and 7.45 [2]. The kidneys make new bicarbonate and excrete acid to keep it there [3], so ordinary amounts of alkaline water do not move it in healthy people. **Reflux.** In a laboratory study, pH 8.8 artesian water irreversibly inactivated human pepsin, the enzyme that damages tissue in reflux, and buffered acid; no patients were treated [8]. We found no trial testing it in people with reflux. **Bone and cancer claims.** A systematic review of 55 studies found no evidence that dietary acid load causes osteoporosis or that an alkaline diet protects bone [4]. A review for cancer found a single eligible study, with no association, and concluded that promoting alkaline diets or water for cancer prevention or treatment is not justified [5]. **What small trials show.** After exercise-induced dehydration, electrolyzed alkaline water lowered high-shear blood viscosity 6.3% versus 3.4% for purified water in 100 adults, with no difference in osmolality or body mass [6]. A bicarbonate-rich mineral water lowered bone-resorption markers over four weeks in 30 young women compared with a calcium-rich acidic water, which points to bicarbonate and minerals more than pH [9]. A 12-week pilot in 40 adults with high uric acid found alkaline water modestly lowered uric acid [10]. **Safety.** The trials reported no adverse events at ordinary intakes [6], but one case report described severe metabolic alkalosis and very low potassium in a woman who drank about 5 liters of alkaline water a day for a month [11]. Many ionizers also advertise “hydrogen-rich” water; see [hydrogen water](/hydrogen-water/antioxidant-and-health-benefits). ## The evidence in detail **Laboratory work on reflux.** Koufman and Johnston tested pH 8.8 artesian well water containing natural bicarbonate. It irreversibly denatured human pepsin in vitro and had a hydrochloric-acid buffering capacity far above two popular bottled waters. There were no human subjects, so this is a mechanism hint, not a treatment result [8]. **Acid-base balance and hydration.** Heil split 38 young adults, matched by sex and activity, into a control group that drank placebo water for four weeks and an experimental group that drank placebo water except for two middle weeks on a mineral-rich alkalizing water of pH 10. The experimental group's reported blood pH rose from 6.23 to 7.07 and urine pH from 7.52 to 7.69, and urine output fell from 2.51 to 2.05 L a day, all reversing after the switch back [7]. Blood pH of 6.23 or 7.07 lies far outside the normal 7.35–7.45 range [2], so those figures probably reflect the fingertip-blood measurement method rather than true blood pH. The trial was also small, matched rather than randomized, and short. Weidman and colleagues ran a double-blind randomized trial in 100 healthy adults (mean age 31). After exercising in a warm room until they lost 2% of body weight, participants rehydrated with electrolyzed high-pH water or standard purified water. High-shear blood viscosity fell 6.30% versus 3.36% (p=0.03). Plasma osmolality, bioimpedance and body mass did not differ [6]. One positive result out of four biomarkers in a single trial is fragile, and viscosity is not a clinical outcome. **Bone.** Wynn and colleagues randomized 30 female dietitians (mean age 26) to 1.5 L a day of an acidic, calcium-rich water or an alkaline water rich in bicarbonate (2,172 mg/L) and calcium (547 mg/L) for four weeks on an identical weighed diet. Parathyroid hormone (p=0.022) and the bone-resorption marker CTX (p=0.023) fell only with the bicarbonate water [9]. The effect came from a large bicarbonate load plus calcium and shows a change in a marker, not in fractures. A systematic review of 55 studies (including 22 randomized interventions, 2 meta-analyses and 11 prospective cohorts, judged against Hill's criteria) found that a causal link between dietary acid load and osteoporosis is not supported, and no evidence that an alkaline diet protects bone [4]. **Cancer.** Fenton and Huang screened 8,278 citations; one cohort study met their criteria and showed no association between dietary acid load and bladder cancer (odds ratio 1.15, 95% CI 0.86–1.55). They found no randomized trials and no studies of alkaline water for cancer treatment [5]. **Does the water contain any alkali?** Piedras and colleagues analyzed five commercial alkaline waters: pH 9.69–10.15, minimal electrolytes, and physiologic alkali under 1 mEq/L, against the 30–60 mEq a day recommended for stone patients needing urine alkalinization. Several ordinary beverages and supplements supplied more alkali, and the authors concluded alkaline water adds no benefit over tap for uric acid and cystine stones [1]. **Observational and pilot data.** In a cross-sectional study of 304 postmenopausal women, regular alkaline-water drinkers had a lower proportion with metabolic syndrome, and lower fasting glucose, waist circumference and diastolic blood pressure, with longer sleep and stronger grip than non-drinkers [12]. Drinkers may differ in diet, income and habits, so this cannot show cause. In a 12-week pilot randomized trial of 40 adults with high uric acid, 1.5 L a day of electrolyzed alkaline water (pH 8.5–9.5) was associated with a larger fall in serum uric acid than purified water, alongside small shifts in gut microbiota. It was small and exploratory [10]. **Harm.** A 42-year-old woman presented with lethargy, vomiting and weakness after drinking about 5 L of alkaline water daily for a month. Her blood pH was 7.69, potassium 1.6 mEq/L and bicarbonate 46 mmol/L, with a prolonged QT interval; she recovered with fluids and electrolyte replacement [11]. One case cannot establish how often this happens, and her history (including pancreatitis) and the extreme intake limit what can be generalized. **Null and conflicting results.** The trials that exist are small, short and measure indirect markers, and they point in different directions: Heil reported pH and urine changes, while Weidman found only a viscosity difference and no change in osmolality. The two systematic reviews on hard outcomes (bone and cancer) found nothing to support the claims [4][5]. **Bottom line (confidence 2 of 5).** Alkaline water is probably no healthier than plain water. Blood pH is regulated whatever you drink, commercial alkaline waters carry little alkali, and the trials are few, small and based on surrogate markers. If you enjoy it, it appears safe in ordinary amounts.