Products · Performance & longevity · Timeline
Timeline Mitopure Softgels
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Purified urolithin A, 500 mg a serving, listed in NSF’s Certified for Sport database. The two company-funded trials missed their main goals, and it costs about $3.30 a day.
Best for Adults who want to try urolithin A at a dose the trials used, and who accept early, company-funded evidence at a high price.
- Our quality rating
- Fair (3 of 5)
- Price range
- Premium
- Verified marks
- NSF Certified for Sport (60 softgels)
- Size
- 60 vegan softgels, 30 servings of 2
approx. $99 for 60 softgels (30 days)
See it on Timeline’s site →We are not affiliated with Timeline. This link goes to the maker’s own page, with no tracking code. How we're funded.
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How we evaluated it
Why we chose it What put it on our list
- NSF lists the 60-softgel pack in its Certified for Sport database, with 37 lots shown. NSF’s mark means a check of the label and a screen for banned substances.
- The label is short and complete: Mitopure (urolithin A) 500 mg per two softgels, plus 15 mg of sodium and 1 g of fat. Other ingredients are vegan softgel, MCT oil, lecithin and annatto. No proprietary blend.
- 500 mg a day is a dose the trials used. Our urolithin A guide lists 500 to 1,000 mg a day for four months, and the middle-aged trial, which had a 500 mg arm, tested Mitopure itself.
- FDA’s GRAS inventory holds a notice for urolithin A from Amazentis, the Swiss company behind Mitopure (GRN 791). FDA’s December 2018 letter says it had no questions. That covers use as a food ingredient at set levels. It is not an approval of this supplement.
Trade-offs What to weigh before you buy
- The evidence is early and the maker paid for it. In both 2022 trials the main goal was missed, and the gains were in secondary results after four months. No trial tested falls, disability or disease.
- It is expensive: $99 for 30 days one time (about $3.30 a day), $89 a month on subscription, about $2.50 a day on the four-month plan. Four months at the label dose costs roughly $296 to $396. The older-adult trial used 1,000 mg a day, twice the label serving.
- Its marketing has needed changes. In May 2025 the National Advertising Division, the ad industry’s self-regulator, found “clinically proven to revitalize mitochondria” supported, but asked Amazentis to make its muscle claims match the study group and to drop a muscle endurance claim whose study dose was twice the recommended dose. Amazentis agreed to comply.
- Timeline’s homepage now says Mitopure is “clinically proven to rejuvenate mitochondria for improved aging” and “#1 Doctor Recommended”. We found no trial of aging outcomes, and the page names no survey or source for the doctor claim.
What to know Details worth knowing first
Urolithin A is a compound that gut bacteria make from the ellagitannins in pomegranates, walnuts and berries. Timeline’s softgel is purified urolithin A, sold as Mitopure, at 500 mg per two softgels. Our urolithin A guide explains the idea and what the trials found.
It is on this list for three reasons. NSF lists the softgels in its Certified for Sport database, the label is one ingredient with its amount, and 500 mg is a dose the trials used. We checked each against its own record, not Timeline’s wording.
The score is a 3, not higher, because of the evidence and the price. Both 2022 efficacy trials were funded by the maker, ran four months, and missed their main goals; the benefits came from secondary results. A month costs about $99, and the older-adult trial used twice the label dose. In 2025 the advertising industry’s self-regulator also asked the maker to change or drop some muscle claims, and the maker agreed. For the wider picture, see energy, aging and mitochondria.
Quality & testing How it measures up against our checklist
- Third-party tested
- Yes
- Tested by
- NSF (Certified for Sport)
| What we checked | What we found |
|---|---|
| Research behind the ingredient Verified | 500 mg a day is the lower dose in the 2022 middle-aged trial of Mitopure (4 months; muscle strength rose, the primary endpoint of peak power did not). The 2022 older-adult trial used 1,000 mg a day and missed both primary endpoints (6-minute walk and muscle ATP); muscle endurance, a secondary endpoint, improved. We read both abstracts on PubMed. Our guide notes the maker funded them. |
| Third-party tested Verified | Listed in NSF’s Certified for Sport database (listing 1635545) as “Longevity Supplement – Mitopure (Urolithin A) Softgels – Timeline”: 60 softgels, serving 2 softgels, 37 lots shown. NSF also lists the berry powder. We found no listing for the gummies. |
| A plain label Maker’s claim | Mitopure (urolithin A) 500 mg per 2 vegan softgels; sodium 15 mg; total fat 1 g. Other ingredients: vegan softgel, MCT oil, lecithin, annatto. We read the Supplement Facts panel Timeline publishes. |
| Claims that match the evidence Verified | Mixed, per an independent review. NAD Case #7234 (May 8, 2025): “clinically proven to revitalize mitochondria” was supported; NAD recommended that “boost muscle function” and “muscle strength increases by up to 12% in 16 weeks” be revised to match the study group (obese, sedentary, middle-aged adults), and that “muscle endurance increases by up to 15% after 8 weeks” be discontinued because the study dose was twice the recommended dose. Amazentis agreed to comply. |
| Homepage aging claim Not verified | Not verified. Timeline’s homepage calls Mitopure “clinically proven to rejuvenate mitochondria for improved aging”. The trials we read measured muscle strength, endurance and blood markers over four months and missed their primary endpoints. The page names no survey for “#1 Doctor Recommended”. |
| Honest cost Maker’s claim | Timeline’s page: $99 one time for 60 softgels (30 days); $89 a month on subscription; $295.97 for a 4-month supply; $827.92 for a 12-month supply. Roughly $3.30, $2.97, $2.50 and $2.30 a day. |
| FDA GRAS notice Verified | GRN 791, urolithin A, notified by Amazentis SA (filed June 15, 2018). FDA’s letter of December 20, 2018 says it has no questions. The intended use is as an ingredient in foods and drinks at 250 to 1,000 mg a serving. |
| Clean Label Project Not verified | Timeline shows a Clean Label Certified logo. The Clean Label Project’s own site has a page titled “Mitopure-Timeline – Vegan Softgels”, dated May 26, 2026. We could not read its detail, so we do not know what it records. |
What the labels mean
- Verified We opened an independent record that confirms it: a certifier’s listing, a regulator’s list or a lab report. It is linked under Sources.
- Maker’s claim The maker says so on its own page or label. We read it but found no independent record.
- Not verified We looked and could not confirm it, or the maker does not say. Treat it as unknown.
Sources Where our facts come from
- Timeline Mitopure Softgels product page: price, dose and claims. Maker’s page. Open ↗
- Mitopure Softgels Supplement Facts panel (image published by Timeline). Maker’s page. Open ↗
- NSF Certified for Sport listing: Longevity Supplement – Mitopure (Urolithin A) Softgels – Timeline. Certifier or regulator listing. NSF has other Timeline listings (older lots, the powder). Check the lot on your pack. Open ↗
- FDA GRAS Notice Inventory: GRN 791, urolithin A. Certifier or regulator listing. A “no questions” letter on a food-ingredient notice. It is not an approval of a supplement. Open ↗
- BBB National Programs: NAD finds some Mitopure claims by Amazentis SA supported (Case #7234, May 8, 2025). Test report. The advertising industry’s self-regulatory review. Amazentis disagreed with parts of the analysis and agreed to comply. Open ↗
- PubMed: Urolithin A in a randomized trial in middle-aged adults (PMID 35584623). Certifier or regulator listing. Abstract. Mitopure at two doses for 4 months. Open ↗
- PubMed: Urolithin A and muscle endurance in older adults (PMID 35050355). Certifier or regulator listing. Abstract. 1,000 mg a day for 4 months in 66 adults. Open ↗
- Clean Label Project site search for “timeline”. Independent source. Lists pages for Timeline’s softgels, powder and gummies. We could not read the detail pages. Open ↗
Alternatives Other options to compare
- Food and exercise first Pomegranate, walnuts and berries supply what gut bacteria turn into urolithin A, though people differ in how much they make. Our mitochondrial health guide puts regular aerobic exercise ahead of any supplement.
- Timeline Mitopure Powder (berry sticks) The same ingredient, also in NSF’s database (3 g sticks). We did not check its price. We found no NSF listing for Timeline’s gummies, so we would pick the softgels or the powder.